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KMID : 0380020200350020150
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Korean Journal of Biotechnology and Bioengineering
2020 Volume.35 No. 2 p.150 ~ p.156
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The Metabolic Activity of Sparassis crispa Extract in Hepatocytes
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Baek So-Jeong
Cho Nam-Joon
Cho Sung-Jin
Kim Eun-Mi
Kim Kee-Kwang
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Abstract
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Sulfonylurea treatment is used for diabetes mellitus, a metabolic disease caused by abnormal absorption of glucose in the body. But it is accompanied by side effects in vivo when taken for a long time. Therefore, there is a need for research on natural materials having similar effects to these therapeutic agents and having fewer side effects that can effectively regulate blood sugar. In this study, we investigated the antioxidative efficacy of Sparassis crispa (S. crispa) extract and the activity of ATP, glycolysis, and mitochondrial membrane potential using human hepatocyte HepG2 cells. As a result, S. crispa extract showed high antioxidant activity and induced a significant increase in HepG2 cell activity and ATP production. S. crispa extract also significantly accelerated the process and mitochondrial membrane potential. Taken together, these results suggest that S. crispa extract has the potential to be developed as a natural material for improving diabetic and diabetic complications by activating hepatic energy metabolism.
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KEYWORD
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Sparassis crispa, glycolysis, mitochondria, hepatocyte, metabolism
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